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Clomiphene is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).
Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.
You should not use clomiphene if you are allergic to it, or if you have:
- unexplained abnormal vaginal bleeding;
- an ovarian cyst that is not related to polycystic ovary syndrome;
- past or present liver disease;
- a pituitary gland or other brain tumor;
- an untreated or uncontrolled problem with your thyroid or adrenal gland; or
- if you are pregnant.
To make sure clomiphene is safe for you, tell your doctor if you have:
- endometriosis or uterine fibroids.
Stomach upset, bloating, abdominal/pelvic fullness, flushing (“hot flashes”), breast tenderness, headache, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: abnormal vaginal bleeding, mental/mood changes.
Vision changes (e.g., blurred vision, seeing spots or flashes) may sometimes occur during clomiphene treatment, especially if you are exposed to bright light. These side effects usually go away a few days or weeks after treatment is stopped. However, in rare cases, vision changes may be permanent. Get medical help right away if any of the following occur: vision problems/changes, eye pain.
This medication may cause a condition known as ovarian hyper stimulation syndrome (OHSS). Rarely, serious OHSS causes fluid to suddenly build up in the stomach, chest, and heart area. This may occur during therapy or after treatment has been stopped. Get medical help right away if you develop any of the following side effects: severe pain/swelling in the lower abdomen (pelvic) area, sudden/rapid weight gain, nausea/vomiting, diarrhea, shortness of breath, decreased urination, pain/redness/swelling of the legs, chest pain, fast/irregular heartbeat.