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Clomid is used to treat infertility in women. It works by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary pituitary or ovarian failure).
Clomid blocks estrogen production, and this stimulates your hypothalamus and pituitary glands to produce gonadotropin-releasing hormone (GnRH), follicle stimulating hormone (FSH) and luteinizing hormone (LH).
The presence of these hormones catalyzes the maturation of the egg follicles, increasing the chances of ovulation.
Clomiphene must be taken by mouth exactly as directed by your doctor in order to be most effective. It is important to follow your dosing schedule carefully.
Your dosage is based on your medical condition and response to therapy. Do not take it more often or for a longer time than prescribed by your doctor. Long-term treatment with this medication is not recommended and should not be more than 6 cycles.
You may be directed to record your body temperature, perform ovulation tests, and properly time sexual intercourse for best results. Ask your doctor if you have any questions.
Along with its needed effects, clomiphene may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking clomiphene:
Check with your doctor as soon as possible if any of the following side effects occur while taking clomiphene:
Less common or rare
- Blurred vision
- decreased or double vision or other vision problems
- seeing flashes of light
- sensitivity of eyes to light
- yellow eyes or skin
Side effects not requiring immediate medical attention
Some side effects of clomiphene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Hot flashes
Less common or rare
- Breast discomfort
- dizziness or lightheadedness
- heavy menstrual periods or bleeding between periods
- mental depression
- nausea or vomiting
- trouble in sleeping
Perform initial complete pelvic and endocrinologic exam. If ovarian enlargement occurs, hold dose until ovaries return to pretreatment size, and reduce dosage or duration of next course. Polycystic ovary syndrome. Discontinue if visual disorders occur. Metabolism disorders (eg, hypertriglyceridemia). Preexisting or family history of hyperlipidemia: monitor plasma triglycerides periodically. Nursing mothers.
You should not use clomiphene if you are allergic to it, or if you have:
- unexplained abnormal vaginal bleeding;
- an ovarian cyst that is not related to polycystic ovary syndrome;
- past or present liver disease;
- a pituitary gland or other brain tumor;
- an untreated or uncontrolled problem with your thyroid or adrenal gland; or
- if you are pregnant.
To make sure clomiphene is safe for you, tell your doctor if you have:
- endometriosis or uterine fibroids.
Do not use clomiphene if you are already pregnant. Talk to your doctor if you have concerns about the possible effects of this medicine on a new pregnancy.
Clomiphene can pass into breast milk and may harm a nursing baby. This medication may slow breast milk production in some women. Tell your doctor if you are breast-feeding a baby.
Using clomiphene for longer than 3 treatment cycles may increase your risk of developing an ovarian tumor. Ask your doctor about your specific risk.